The technology - XtriG
The traditional routes of drug administration are intravenous (injection), per oral (tablet), inhalation (spray), trans dermal (patch), and rectal (suppository). There traditional preparations are being challenged by new preparation technologies that aim for improved properties such as availability, onset, and uptake.
Release directly to the bloodstream via the mucosa of the lip
XtriG brings a completely new technology of drug preparation. By means of the technology, drugs can be administered at the oral mucosa using a membrane. Instead of ingesting a tablet, taking a detour via the gastrointestinal tract, the membrane is applied under the upper lip where the saliva releases the drug directly to the bloodstream via the mucosa for a direct effect. XtriG is an excipient for the purpose of carrying the substance to the site of absorption.
The technology does not change the original substance, it only offers a new way of preparation. The mucosa under the upper lip are among the most delicate in the body, and prior studies have shown them to be very suitable for absorbing drug substances.
Instead of ingesting a tablet, taking a detour via the gastrointestinal tract, the membrane is applied under the upper lip where the saliva releases the drug directly to the bloodstream via the mucosa for a direct effect.
NorInvent's Drug Delivery platform, XtriG, is based on a patented carbohydrate structure that can bind a drug substance. Carbohydrate and drug is then attached to a membrane, which is the physical transporter of the compound.
Released by the saliva
The chemical bond between XtriG and drug is released by the saliva in the mouth. The release is instant when the membrane is applied under the lip after which the drug substance is transported via the oral mucosa directly to the bloodstream. The substance can have an effect in 5-10 minutes.
The technology is not suitable for all types of drugs and there are limitations in binding and uptake.
The chemical bond between XtriG and drug is broken naturally by the saliva in the mouth causing the drug substance to be transferred directly to the oral mucosa.